Places to start.

Antigua Pedestrian centro on cobblestones. Cars stop at the ring; overnight parking is off the grid. See stays Erik Cleves Kristensen · CC BY 2.0 · Wikimedia Commons Atitlán Public lanchas leave Panajachel Tzanjuyú dock. Tuk-tuks meet the boat. See stays toby_Argüelles · BY-SA 2.0 · Openverse Xela Highland centro. Cold nights, Parque Central as the pin. See stays Adam Jones · CC BY-SA 2.0 · Wikimedia Commons Retalhuleu CA-2 Pacific slope. IRTRA / Xetulul is the landmark. See stays Konjiki1 · CC0 · Wikimedia Commons Guatemala City Zones 4 and 10 hold the walkable blocks. The airport sits at the southern edge of zone 13. See stays Gobierno de Guatemala · Public domain · Wikimedia Commons Flores / Tikal Flores island is the base; Tikal is an hour north by road. Shuttles leave before dawn for the sunrise gate. See stays Dennis G. Jarvis · CC BY-SA 2.0 · Wikimedia Commons Monterrico Black-sand Pacific beach reached by the La Avellana car ferry. The last crossing is early evening. See stays mardoqueo sagastume · CC BY 3.0 · Wikimedia Commons Semuc Champey Lodges sit around Lanquín. The last stretch to the pools is unpaved and 4x4 only. See stays Christopher Crouzet · CC BY-SA 3.0 · Wikimedia Commons Livingston Garífuna Caribbean town with no road in. Boats run from Puerto Barrios and down the Río Dulce. See stays Globetrotteur17 · BY-SA 2.0 · Openverse El Paredón Black-sand surf village on the Pacific, about two hours from Antigua. Shared shuttles run daily. See stays Gobierno de Guatemala · Public domain · Wikimedia Commons Huehuetenango Highland capital near the Pan-American Highway. The Zaculeu ruins sit at the edge of town; the Cuchumatanes rise to the north. See stays Simon Burchell · CC BY-SA 4.0 · Wikimedia Commons Cobán Alta Verapaz capital in misty coffee and cardamom hills. The usual overnight on the road to Lanquín and Semuc Champey. See stays Gobierno de Guatemala · Public domain · Wikimedia Commons Esquipulas Pilgrimage town of the Black Christ basilica, near the Honduras and El Salvador borders. Busiest around 15 January. See stays JMRAFFi · CC BY-SA 4.0 · Wikimedia Commons Río Dulce River town at the Lake Izabal bridge. Boats run down the gorge to Livingston; the San Felipe fort is a short ride away. See stays Adam Jones · CC BY-SA 2.0 · Wikimedia Commons